Gout Increases Vascular Disease Risk For Both Men And Women

Gout Linked to Increased Vascular Disease Risk

Patients with gout, particularly women, have increased risk for vascular disease, according to findings of a study published online August 27 in the Annals of Rheumatic Diseases. vascular-disease

Hyperuricemia (high Uric Acid), the biochemical precursor to gout, has been linked with an increased incidence of, and mortality from, both Coronary Heart Disease (CHD) and Stroke,” writes Dr. Lorna E. Clarson, MBChB, from the Research Institute for Primary Care & Health Sciences at Keele University in the United Kingdom.

“Although gout is traditionally thought of as an intermittent inflammatory condition, recent ultrasound studies have identified persistent subclinical inflammation in the inter-critical period between acute attacks. It has been hypothesized that the combination of persistent inflammation and hyperuricemia may potentiate or synergize CHD development.”

Dr. Clarson and colleagues examined the association of gout with CHD, Cerebrovascular Disease (CVD), and Peripheral Vascular Disease (PVD) in a large study of primary care patients with gout.

8386 patients with gout were matched on the basis of age and sex with 39,766 control participants. All were older than 50 years and had no previous vascular disease history.

Gout Related Vascular Disease Results

Men with gout had a small but significantly elevated risk for any vascular disease event compared with men without gout. Similarly, men with gout had a greater risk for any CHD and PVD.

Among women with gout, the risk was much greater, with the risk of any vascular event being 25% higher than those women without gout. The risk for any CHD and PVD was also higher in those women with gout, but the researchers found no difference for risk for any CVD among the two groups of women.

In addition, women with gout, but not men with gout, were at increased risk for angina, transient ischemic attack (TIA), and stroke.

“In this cohort of over 50’s with gout, female patients with gout were at greatest risk of incident vascular events, even after adjustment for vascular risk factors, despite a higher prevalence of both gout and vascular disease in men,” the study authors write.

Ann Rheum Dis. Published online August 27, 2014. Full text